What you're suggesting would not improve the speed and performance of the drive in fact it would make things worse.
It's true files at the start of the drive load quicker, however priority should be always given to Operating System files and applications if you want an optimised file system.
Files that are stored and do not change should also be located at the start of the disk not changeable files as I'll try to explain.
When you move changeable files to the start of the drive there would be very little contiguous freespace for them to move into.
Therefore Defraggler must make room for this space by moving other files away to another area of the disk.
Once the freespace has been made Defraggler would move all the changeable files to the start of the disk all in a neat order: Firefox and Internet Explorer cache files (useless files) and probably VirtualBox / VMWare OS hard disk images etc.
So now everything has been defragged you would probably thinking well what could go wrong with this arrangement??
The problem is that your files are highly likely to quickly fragment and degrade the performance of the file system.
When a file expands it first uses it's cluster allocations, when this has gone it needs to get more free clusters.
Because all your files are neatly packed at the start of the disk all nearby clusters are in use would force the OS to use free clusters at some distance from the main file.
Now if you prioritise files that do not change to be located at the start of the disk fragmentation would still happen for changeable files but their fragments would be closer together and thus the disk head would have little distance to move.
So:
1: the read heads have to move less to find the needed files
The head is constantly swinging back and forth a few fragmented files isn't really going to make that much difference.
2 big performance boost
I've often wondered if you get much performance boost by Optimising the file system so I used a rival freeware defragging tool and let it organise my files in the optimum pattern.
After 10 minutes of shuffling around I have to be honest I saw no improvements, apart from Windows loading my desktop 2 seconds faster than previously.
As long as you defrag once every 3 months you're not going to see any big performance boost by defragging your drive once a week or every day.
3 less wearing on hard drive
Constant and unnecessary defragging would always wear your hard drive out.
4 less fragmented files
Files always fragment it's the nature of the file system.
However, files located at the start of the disk that fragment will degrade your file system more than fragmented files located at the end of the disk.
5 would not need to defragment drive so often
Same as 2.
Richard S.