We are running CCleaner network in an Active Directory environment. We have CCleaner perform scheduled scans on computers in the domain on a daily basis. Ever since we started the scheduled scans, we have been having issues with corrupted user profiles. The corrupted profiles issues happen on a weekly basis on random users. When it happens, the user is not able to login to their computer unless an administrator, deletes their profile from HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList on the machine, renames the profile on the c:\ drive, have the user logon with a clean profile and restore their profile settings.
Although I can't 100% rule it out, I don't believe the corrupted user profile problem is caused by CC.
I used to only see this about once or twice a year, I'm now seeing it occur maybe 1 a month, with no common factor to point the blame at.
Some people have not done Windows Updates, nor AV updates, nor ran CC, etc, yet this is happening, seemingly, randomly.
I've been logging in with Safe Mode, copy the user account data somewhere, delete that corrupted account, log on normally, have Windows recreate the profile and copy their data back.
Annoying but easy enough. Hasn't happened yet to the same PC twice, and most are still using CC.