CCleaner & Safe Mode.

Was just wondering if there is any advantage in using CCleaner in safe mode. Some programs need sometimes to be used in safe mode to do a thorough cleaning once in a while. Can I do so with CCleaner once in a while? Am very satisfied with CCleaner. Thanks.

I don't believe there are any advantages in using CCleaner in safe mode any files it cant remove will be removed on the next boot.