If ccleaner works for you in safe mode it points to it being perhaps a conflict with something you have running when in normal mode. This something doesn't load it's drivers when you start in safe mode.
Troubleshooting this would need you to test each startup item and could be quite time consuming. Only you can decide if you want to go down that road.
Even if you decide not to because you cannot face the hassle, don't worry about it, you're still very welcome here
No one has suggested the thread is too long. I think you misread something one of the other guys said.
A topic can get as long as it needs to until a solution is found or not, and I don't really think it was sidetracked either, as sorting out your A/V situation was relevant to generally trying to find the cause of your problem.
No one's in any hurry here to close the thread, and we're happy to take as much time as it needs as long as you don't get fed up and frustrated yourself with the fact that it isn't straightforward.
Hazel's "Safe Mode" suggestion has pinpointed where the problem lies, but it will take a bit of work to isolate the little bugger behind the problem.
And I'll second what hazel says. If you're fed up with it and want to call it a day that's fine, but you can come back to it, or any other problem, any time you like. We aren't going anywhere.