After starting CCleaner (currently running V4.17.4808) the screen opens, but both the "Analyze" and "Run Cleaner" buttons will be grayed out for 1 to 10 minutes (varries each time I open) before I can run CCleaner to clean up my hard drive.
This has been happening for the last several months and before (since around 415 I believe).
Same thing happens when I have it open when my system starts, it wont start the auto clean on system start for 1-10 minutes or so.
It's scanning for installed programs. Are you running a large winapp2.ini file such as the entirety of the template shared in the thread of this board. Or maybe you are using some sort of "enhancing" program for ccleaner
Something to try to see if it's antivirus related (might not be though):
* Virus scan the CCleaner program files folder before you run CCleaner.
* Open CCleaner after the virus scan completes.
If CCleaner opens quick and is usable it could be due to the antivirus.
Also, and perhaps related, visit the Microsoft Updates website and have it download+install any available Root Certificate updates it shows are available. Doing this may allow digitally signed software (all Piriform software is digitally signed) to work correctly, especially if it's a certificate problem.