When something is 'Skipped' during cleaning it's an indication the the application is still open, or running in the background.
Even when you have closed it, it may still be running something in the background.
By default CCleaner's Custom Clean asks if you want to close the still running app, but if you have ever replied to one of those messages with a 'Do not show me this message again' then it won't ask in future and will just 'skip' the app if it's still running.
Health Check should ask every time, the message box is slightly different.
To prevent Edge from running in the background:- go into the Edge settings and turn off both 'Startup Boost' and 'Continue running background extensions and apps .....
That will prevent the background running of Edge and let CCleaner clean it.
For other apps (such as the Windows Store) you have to go to the Windows Settings>Privacy>Background apps
Once there you can turn off background running for all apps, or scroll through the list and turn them on/off individually: