Ccleaner Messed Up System

I ran ccleaner to clean up my system as it was running slowly. I left the default settings made a backup of the registry. When it was done I immediately got an error that my touchpad enhancements stopped working, then I restarted and noticed that my speakers no longer worked, and the buttons on my computer such as volume up and down or brightness don't show up on the screen like it used to.

I system restored to the previous day... it didn't work. I merged the reg file with the backup... it didn't work. So now I don't know what to do.

I have a Lenovo T400 with 64 bit vista