I see there is a sticky for using CCleaner in a domain environment, but I have a little twist. All our users have roaming profiles, and their Application Data folder is redirected to a network share. I can only imagine the loads of crap wasting space on my server from a couple hundred people. Everyone's Application Data folder is in their own D:\Home\UserName folder.
Instead of having each user have to run ccleaner from their local computer as that sticky suggested, which would make it run across the network, is there any way to just run it from the server on all of them in that D:\Home directory structure? I'm guessing not since that wouldn't give the program access to the registry. But I'm wondering if there is a way to "trick" ccleaner into using a "default" registry to know where the crap would be located in each (if that makes sense to anyone other than me haha).