Thank you Nergal; no, CCleaner has not been running whilst trying to update. That said, I have just this last hour, solved the problem (a Google search result from back in 2015) and was about to post this fact. In short, the permissions within the CCleaner program itself needed granting to me as user even though I already have Administrator permissions within Windows 10. So, now within the CCleaner program, there are granted permissions ('Fully') for user and Administrator and that seems to work. Something changed with this most recent update but, interestingly, it's only affected my two Dell Desktops but didn't affect my Toshiba laptop which updated fine as soon as the new version was released. So, hopefully all will now be good. Stephen.