AFTER CLEANING MY REG THIS KEEPS COMMING UP EVERYTIME IN WINDOWS 10.

LOCAL SERVER 32\C\WINDOWS\SYSWOW64\SPEECH ONECORE\COMMON\SPEACHRUNTIME.EXE-TOASTNOTIFER HKCR\CLSID\{265B1075-D22B-BC97-8756F3E6DAB}

WHAT IS THIS AND WHY CAN CC CLEANER NOT FIX IT ?

Please refrain from using all capital letters, it's considered shouting on the web.

That reg key is a known issue, cleaning it is futile. For an explanation read this post by Nukecad:

https://community.ccleaner.com/topic/60480-cwindowssyswow64speech_onecorecommonspeechruntimeexe-toastnotifier/?do=findComment&comment=329122