I used CCleaner in the Windows 7 Beta without any majorly apparant issues, but the RC seems to be antoher story all together, as CCleaner apparantly breaks enough features to make using the program too risky for the time being.
Granted, this is somewhat expected in a prerelease OS, but as 7 is (from latest reports) only about 4 months from release, hopefully these bugs can start to get ironed out.
A few big problems I've noticed in the last 48 hours of playing with the RC:
1. Running CCleaner completely breaks the new Devices and Printers control panel. The green progress bar just scans very slowly accross the screen, and will just hang when it reaches the far right side. If you cancel the scan, either 0 items will be shown in the folder (in the lower left status bar text) or a random number of items may said to be in the folder, but are not visible or accessible in any way (IE you can't use or configure any of the installed devices that should be shown here.)
2. CCleaner also breaks both the "Bluetooth" and "Safely Remove Hardware" icons functionallity in the notification area. You can click on them, but they no longer do anything. This is possibly related to the fact that these items would normally show up in the (now broken) Devices and Printers control panel.
3. CCleaner somehow breaks the Task Scheduler, as opening the console window simply gives you error messages about missing tasks and Task Scheduling functionality no longer seems to work at all.
4. The Display Color Calibration wizard is unable to save calibrated settings to a profile after running CCleaner.
I'm using the latest version of CCleaner with all availible cleaning options checked. I'm not sure if each of these are caused by file or registry cleaning, but will be playing around in a virtual machine to see if I can find the specific cause for each of them and will post a follow-up if I can pinpoint them.
Thanks in advance for the continuing work on a great app.