Add me to the list too, for Ccleaner always having to close Edge before running.
Just last week I installed a brand new SSD and did a fresh Win10 install on it. That's when Ccleaner started having this problem. I never use Edge as I'm satisfied with Chrome. I do use Firefox for all youtube videos as the AdBlock kills all those annoying commercials, but for everything else I use Chrome.
The only time Edge opened is by default just after the Win10 install, when it opens to msn.com, trying to become your home page. You pretty much have to use Edge to download Chrome so you can change browsers.