Yes, ccleaner has stopped working since the latest upgrade on my machine, also. Windows 10, ccleaner v5.42.6495 (64 Bit). It opens as usual, and the 'Analyze" button performs as it should. As soon as I click 'Run' it either opens a "Program stopped working" window or just simply shuts down and disappears. I have tried uninstalling and reinstalling the entire program; that does not resolve the issue.