Thank you for your help, this was the case! I have found the portable.dat file in the installation folder. I deleted it and restarted the ccleaner. Now the options are active. I'am still not sure, where I have downloaded the portable version. Uninstalling did not helped to remove the portable.dat file, so after i have installed the fresh version, the system behaved again the same way. It would be good, if ccleaner will display somewhere (maybe in the header banner), that portable version is running.