Changes I made to reduce Defraggler run time from more than a day to less than 6 hours for 1TB on Windows 7
Defrag was super slow prior to doing this.
Go to Settings > Options > Advanced tab
Check - Save all settings to INI file
Check - Stop VSS when defragmenting NTFS volume
Check - Use custom fragmention settings: - click Define button - check box on both options: Exclude restore point, and, Exclude hibernation file.