Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Uninstall\TweakUI]
"DisplayName"="Tweak UI"
"UninstallString"="C:\\WINNT\\rundll32.exe syssetup.dll,SetupInfObjectInstallAction DefaultUninstall 4 C:\\WINNT\\Inf\\Tweakui.Inf"
This entry gets marked by ccleaners issues section as an uninstaller reference issue.
It is a perfectly legitimate albeit unusual uninstaller reference.