Hey CCleaner cleans the Obsolete and other invalid entries, uninstalled programs- old pointing locations because its old and the new program will not use the same its obsolete.
I checked the file attached: here when you run any application there will be a temp registry entry for running the application successfully, after closing the application the registry entry made by the application is invalid, that's why its coming in the reg-clean.
nothing to worry its only cleaning the unwanted. I am using CCleaner for last 3 yrs and my PC didn't got any issues rather it made faster by removing all unnecessary and invalid, obsolete reg entries.