Oh wow, I'll be sure to use that options, 'cause an .ini file would come in handy now. That's just really useful, yay Piriform!
I assume you mean the default one in system32?
Now, here's where it gets weird. It's a great idea to use RegEdit to fix this, 'cause I actually know what you're talking about and have used it before. However it's... it's exhibiting the same problem. It opens and closes itself within a second. And it's just this, nothing else has been affected, so it's not any kind of malware. CCleaner and the regedt32.exe in system32 are the only two problems not working.