I found that if you turn off and then on the Inbound/Outbound MailSafe Protection (or vice versa) in the ZoneAlarm setting (email protection window), the data in the registry is changed to C:\Program Files\Zone Labs\ZoneAlarm\zonealarm.exe,-279, which CCleaner won't be upset by as it's a proper path. So that is an easy, if somewhat unexpected way to correct that registry key