I have spent over 10 total hours on the phone with Microsoft to get my office working again. I had both office 2019 and 2021 and both stopped functioning a few months ago. Decided to upgrade to 365 but alas the same issues. None of the office apps (Outlook, Word, Excel, Powerpoint) would open. Microsoft online got into my system and after various tried attempts made some registry entries to get it working again. This happened three different times but after a few days it would happen again and again. I installed and reinstalled Office on numerous occasions on my own and with Microsoft helping me. I have run Microsoft scrub to completely uninstall and then reinstalled with no luck. Did some research and found some other people with the same issues and recommended uninstalling CCleaner, so a few days ago I uninstalled my CCleaner Pro program. Office has been working perfect since. I know it has only been a few days but so far so good. Just for info purposes I had completely reinstalled Windows 11 with no change. It was only after uninstalling CCleaner that my Office is now working perfectly again. With all the positive comments I have seen for CCleaner this has been a major problem for me. I was able to find a few posts on this site regarding this subject matter and really wish I had found it sooner but didn't know the cause was CCleaner until recently. There is no doubt in my mind that this was the issue.