I had to uninstall CCleaner because it was interfering with Windows 10: during startup, a message window would appear asking me to give permission for Piriform. When I clicked "Yes", the screen went completely black, with only the mouse showing. This message window never appeared when I was running Windows 8.1
After installing Windows 10, this message window always appears. I always clicked "yes" and had no problems until about 10 days after installing Windows 10, when the above problem happened. On reboot, I clicked "No", but the screen still went black. Rebooted again, and again clicked "No". This time, success. My usual desktop appeared and was stable.
A call to Fujitsu tech support generated the suggestion that I uninstall CCleaner, which I have done. There has been no repeat of the problem, which suggests CCleaner was causing it.